Synthesis of heterocyclic bromacetylene alcohols and their acryl -, methacryl ethers

The article presents a method for obtaining heterocyclic bromoacetylenic alcohols by the action of sodium hypobromide on cyclic and heterocyclic acetylene alcohols, as well as their acrylic and methacrylic esters using lithium aluminum complexes. The composition and structure of the obtained products were confirmed by the data of elemental analysis, IR and PMR spectra. As a result of the study, it was found that in the presence of lithium aluminum hydride, the product yield in all cases is higher than 80 %.

1. Azerbaev I.N., Sarbaev T.G., Yagudeev T.A. Syntheses based on petroleum hydrocarbons. -Alma-Ata: Nauka, 1974. - 224 p. [in Russian].

2. Praliev K.D., Sokolov D.V., Khokhlov E.I. Synthesis and stereochemistry of phenylethynylation of 1-(2-ethoxyethyl)-3-methylpiperidin-4-one // Chem. pharm. Journal. - 1986. Volume 20, № 6. - Р. 679-683. [in Russian].

3. K.M. Toktagulova, N.U. Aliev, T.A. Yagudeev Synthesis of phosphorylated enines by the Michaelis-Becker reaction // Chemical Journal of Kazakhstan-2017.-Volume 1, № 57-Р. 60-62. [in Russian].

4. P.R. Likhar, M.S. Subhas, S.Roy, M.L. Kantam, B. Sridhar, R.K. Seth, S. Biswas. Org. Biomol.Chem. 2009. - Issue 7. - P. 85