Development of a methodology for obtaining herbal pharmaceutical substances for the production of phytoproducts

Modern trends in the pharmaceutical industry are characterized by a steady increase in interest in herbal remedies, driven by increased attention to the safety and efficacy of drugs, as well as the global desire to use environmentally friendly and renewable raw materials. Under these conditions, the development of scientifically based technological approaches aimed at ensuring the stability of the composition and reproducibility of the quality of herbal products is of particular importance.This paper presents a methodology for obtaining medicinal herbal raw materials of pharmacopoeial quality, based on the application of the Quality by Design concept and the Design of Experiments tool. The studies were carried out using the above-ground parts of the plants Seseli sessiliflorum Schrenk, Dracocephalum bipinnatum Rupr., Dracocephalum integrifolium Bunge, Dracocephalum ruyschiana L. and Ziziphora bungeana Juz., which are characterized by a high content of biologically active components, including essential oils, flavonoids and phenolic compounds with pronounced biological activity. The study assessed the influence of harvesting, drying, grinding, and storage parameters on the preservation of heat-labile components and the stability of the chemical profile of the studied raw materials. The developed methodology for obtaining plant raw materials holds great promise for the subsequent development of drugs, dietary supplements, and cosmetics with predictable quality and effectiveness, as well as for improving the standardization and quality control system for plant materials in accordance with international requirements.

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