Development of dressing materials with plant-based antimicrobial components

Antimicrobial dressing materials play an important role in the treatment of infected wounds. They help control microbial complications, prevent the development of chronic inflammation, and promote faster skin regeneration. Such materials are used to protect against infection in the treatment of chronic wounds (e.g., trophic ulcers, diabetic foot ulcers), burns, and infected postoperative wounds where there is a high risk of complications. Currently, the potential use of natural substances as antibacterial agents in dressing materials is being actively studied. Scientific data confirm the effectiveness of such substances as propolis, honey, chitosan, and essential oils. These components possess mild but persistent biocidal activity and do not cause side effects. As part of our research, gauze samples treated with two different formulations were exposed to soil microflora to determine the microbiological resistance coefficient. Untreated gauze samples, when exposed to microflora, began to mold and decompose, whereas materials treated with natural biocides showed significantly lower levels of degradation. Particularly high microbiological resistance was observed in samples treated with a formulation based on wormwood extract and chitosan. To assess the morphological changes in the fibers after treatment, a study using a scanning electron microscope was conducted. A uniform distribution of biocidal particles on the fiber surface was observed. At the same time, the air permeability and absorbency of the treated gauze materials remained largely unchanged. 

1. Mouro, Cláudia, & Gouveia, Isabel C. (2023). Electrospun wound dressings with antibacterial function: a critical review of plant extract and essential oil incorporation. Critical Reviews in Biotechnology, 44(4), 641-659. DOI:10.1080/07388551.2023.2193859.

2. Gheorghita, Daniela, Grosu, Elena, Robu, Alina, Ditu, Lia Mara, Deleanu, Iuliana Mihaela, Gradisteanu Pircalabioru, Gratiela, Raiciu, Anca-Daniela, Bita, Ana-Iulia, Antoniac, Aurora, & Antoniac, Vasile Iulian. (2022). Essential Oils as Antimicrobial Active Substances in Wound Dressings. Materials (Basel), 15(19), 6923. DOI:10.3390/ma15196923.

3. Ersanli, Caglar; Voidarou, Chrysoula (Chrysa); Tzora, Athina; Fotou, Konstantina; Zeugolis, Dimitrios I.; & Skoufos, Ioannis. (2023). Electrospun Scaffolds as Antimicrobial Herbal Extract Delivery Vehicles for Wound Healing. Journal of Functional Biomaterials, 14(9), 481. DOI:10.3390/jfb14090481.

4. Suryamathi, M., Viswanathamurthi, P., & Seedevi, P. (2022). Herbal Plant Leaf Extracts Immobilized PCL Nanofibrous Mats as Skin-Inspired Anti-infection Wound Healing Material. Regenerative Engineering and Translational Medicine, 8, 94-105. DOI:10.1007/s40883-020-00193-9.

5. Tohidi, Azadeh; Montazer, Majid; Mahmoudi Rad, Mahnaz; et al. (2024). Biocompatible Polysaccharide-Based Wound Dressing Comprising Cellulose Fabric Treated with Gum Tragacanth, Alginate, Bacterial Cellulose, and Chamomile Extracts. Starch - Stärke, 76(7-8), 2300117. DOI:10.1002/star.202300117.

6. Rayyif, S. M. I., Mohammed, H. B., Curuțiu, C., Bîrcă, A. C., Grumezescu, A. M., Vasile, B. Ș., Dițu, L. M., Lazăr, V., Chifiriuc, M. C., Mihăescu, G., & Holban, A. M. (2021). ZnO Nanoparticles-Modified Dressings to Inhibit Wound Pathogens. Materials, 14(11), 3084. DOI:10.3390/ma14113084.

7. Ali Alipour, Omid Nejati, Gökçen Yaşayan, Ayça Girgin, Buse Tuğba Zaman, Betül Giray, Okşan Karal-Yılmaz, Sezgin Bakırdere, Ayça Bal-Öztürk. (2025). Multilayer Antibacterial Hydrogel Wound Dressings Incorporated With Green Synthesized Silver Nanoparticles. Drug Development Research, 86(3), e70102. DOI:10.1002/ddr.70102.

8. Zheng, Lu; Li, Shanshan; Luo, Jiwen; Wang, Xiaoying. (2020). Latest Advances on Bacterial Cellulose-Based Antibacterial Materials as Wound Dressings. Frontiers in Bioengineering and Biotechnology, 8, Article 593768. DOI:10.3389/fbioe.2020.593768.

9. Rayyif, Sajjad Mohsin I.; Mohammed, Hamzah Basil; Curuțiu, Carmen; Bîrcă, Alexandra Cătălina; Grumezescu, Alexandru Mihai; Vasile, Bogdan Ștefan; Dițu, Lia Mara; Lazăr, Veronica; Chifiriuc, Mariana Carmen; Mihăescu, Grigore; Holban, Alina Maria.ZnO Nanoparticles-Modified Dressings to Inhibit Wound Pathogens.Materials, 2021, 14(11), 3084.https://doi.org/10.3390/ma14113084.

10. Babahmadi, M., Yeganeh, H., Omrani, I., Babaahmadi, M. (2023). Antibacterial and Biocompatible Hydrogel Dressing Based on Gelatin- and Castor-Oil-Derived Biocidal Agent. ACS Biomaterials Science & Engineering, 2021, 7(4), 1785-1798. DOI:10.1021/acsbiomaterials.1c00706.

11. Pang, Qian; Jiang, Zilian; Wu, Kaihao; Hou, Ruixia; Zhu, Yabin. (2023). Nanomaterials-Based Wound Dressing for Advanced Management of Infected Wound. Antibiotics, 12(2), 351. DOI:10.3390/antibiotics12020351.

12. Liang, Yuqing; Liang, Yongping; Zhang, Hualei; Guo, Baolin. (2022). Antibacterial biomaterials for skin wound dressing. Asian Journal of Pharmaceutical Sciences, 17(3), 353-384. DOI:10.1016/j.ajps.2022.01.001.

13. Plant-Derived Nanocellulose Sponges with Propolis Extract: Plant-Derived Nanocellulose with Antibacterial Activity for Wound Healing Dressing. Pharmaceutics, 15(12), 2672. DOI:10.3390/pharmaceutics15122672.

14. Morguette, A. E. B., Bartolomeu-Gonçalves, G., Andriani, G. M., Bertoncini, G. E. S., Castro, I. M. d., Spoladori, L. F. d. A., Bertão, A. M. S., Tavares, E. R., Yamauchi, L. M., & Yamada-Ogatta, S. F. (2023). The Antibacterial and Wound Healing Properties of Natural Products: A Review on Plant Species with Therapeutic Potential against Staphylococcus aureus Wound Infections. Plants, 12(11), 2147. DOI:10.3390/plants12112147.

15. Polymer-Based Wound Dressings Loaded with Essential Oil for the Treatment of Wounds: A Review. Pharmaceuticals, 2024, 17(7), 897. DOI:10.3390/ph17070897